Formulation Development and Evaluation of Fast Disintegrating Tablets of Salbutamol Sulphate for Respiratory Disorders: A Review

Abstract

Recent advances in rapidly dissolving formulations have increased dosing for children and elderly patients who have difficulty swallowing chemotherapeutic agents currently aims to prepare rapidly dissolving salbutamol sulfate tablets for respiratory problems for pediatric treatment. While accurate dosing and patient compliance will be important prerequisites for long-term therapy, it is important to develop pharmacological interventions that address swallowing disorder, easy transportation, patient acceptance etc. The present study was therefore conducted with the intention of providing a readily soluble salbutamol sulfate with suitable alternatives. Highly corrosive compounds such as sodium starch glycolate were successfully developed. Binders were optimized with an optimal amount of hyperseparator. Tablets were prepared using direct compression technique. The tablets were evaluated for hardness, brittleness, weight change, wetting time, cracking time, and uniformity. The optimized formulations were evaluated by in vitro dissolution testing, pharmaco-excipient compatibility, and rapid stability studies. The conclusion was that a fast-dissolving solution of salbutamol sulfate with desirable fast-dissolving properties was successfully developed; provided a quick start to the process; and increased patient convenience and compliance.

Keywords: disintegration, treatment, drug evaluation, polyvinylpyrrolidone, microcrystalline, salbutamol sulfate.