Synthesis, biological evaluation, and analytical study of 5– [4-(4-substituted amino-3- nitrobenzene-1-sulfonyl)-4,5,6,7–tetrahydrothieno[3,2-c] pyridine

Abstract

A novel series of 5– [4-(4-substituted amino-3-nitrobenzene-1-sulfonyl)-4,5,6,7–tetrahydrothieno[3,2-c] pyridine] derivatives was synthesized through a multi-step synthetic route involving sulfonylation, nitration, and heterocyclic cyclization reactions. The structural identity of the synthesized compounds was confirmed by analytical techniques such as FTIR, NMR, and mass spectrometry. Biological evaluation was carried out to assess antimicrobial, anti-inflammatory, and antioxidant activities. Several compounds exhibited promising bioactivity, demonstrating structure–activity relationships dependent on the nature of the amino substituent. These findings highlight the potential of thienopyridine-based sulfonamides as lead compounds for pharmaceutical development.

Keywords: NMR, Mass, IR HNMR, analysis, synthesis.