An Overview of Novel Techniques employed in Mouth Dissolving Drug Delivery System

Abstract

Mouth-dissolving drug delivery systems can be manufactured by a variety of technologies, including direct compression, wet granulation, freeze drying, spray drying, vacuum drying and use of superdisintegrants. Fast Dissolving drug delivery system (FDDS) that includes Mouth Dissolving tablets (MDTs) and Mouth Dissolving films (MDFs). FDDS have been defined as “A solid dosage form containing medicinal substances which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue”. United States Food and Drug Administration further defines FDDS as solid oral preparations that disintegrate rapidly in the oral cavity, with an in-vitro disintegration time of approximately thirty seconds or less. Initially the FDDS were introduced as MDTs in 1970’s as an alternative to the conventional tablet and capsule which require swallowing of the dosage form and latter on MDFs was introduced in 2001. They undergo disintegration or dissolution in the saliva generally within few seconds to a minute releasing the drug and inactive ingredients into the oral cavity. The major amount of the drug will eventually be swallowed with the saliva and transported along the GIT where the drug is subsequently absorbed. This review article was emphasized on the various novel techniques applied to develop a FDDDS and their applications in the field of pharmacy.

KEYWORDS: Quick dissolving dosage forms; slow dissolving DDS; non dissolving DDs, Novel technology of FDDDs.